Mitsuki was created as a synthetic human by Orochimaru, being cultivated from the same embryo as at least one older "Mitsuki". Orochimaru, as Mitsuki's "parent", wanted Mitsuki to find his independence, having concocted a complex plot for Mitsuki to do so. On Orochimaru's sixth attempt of the plan, each time erasing Mitsuki's memories of the previous, Mitsuki mastered Sage Transformation and decided to rebel against his "parent" and "older brother". He left their company and set out to forge his own destiny himself, now going by the name "Mitsuki" by replacing the second character with "Tsuki". Upon discovering the existence of Boruto Uzumaki via a gift from Orochimaru, Mitsuki decided to go to Konoha and befriend him in order to find his own path in life.