According to Hokkoku Newspaper, Yuwaku Hot Spring , the model town of Hanasaku Iroha, has been humming with business since the start of the anime. After the earthquake in March, nearly 1,500 guests have canceled the hotel reservations in Yuwaku but the rooms of all the nine hotels were fully booked by the anime fans just before the holidays in May. The bottles of Yuwaku Cider have been flying off the shelves because the cider was shown in the ED.

Iroha fans taking pictures of the sign of the model train station

Comparisons between the real sceneries in Yuwaku and the scenes in the anime
Entrance of the hotel area
Yuwaku - Anime

Main street
Yuwaku - Anime

Bridge Ohana walks on
Yuwaku - Anime

Bench Yuina sits with a Yuwaku Cider
Yuwaku - Anime

The rival hotel
Yuwaku - Anime

Yuwaku Spa Tourist Association said they expect the anime fans to visit the town repeatedly.

Source: Hokkoku Shinbun