Here is the yearly anime single CD ranking for 2010. (Dec 28 2009 - Dec 20 2010)

*1, 147,479 Angel Beats! "My Soul, Your Beats!" "Brave Song"
*2, 147,355 K-ON!! "Go! Go! Maniac"
*3, 133,922 K-ON!! "No, Thank You!"
*4, 130,957 Dragon Ball Kai "Kokoro no Hane"
*5, 130,137 K-ON!! "Liten!!"
*6, 129,309 K-ON!! "Utauyo!! Miracle"
*7, *99,176 Sengoku Basara Two "Sword Summit"
*8, *97,039 Mobile Suit Gundam 00 The Movie: A Wakening of the Trailblazer "Qualia"
*9, *93,759 Mahou Shoujo Lyrical Nanoha The Movie 1st "Phantom Minds"
10, *81,405 Angel Beats! "Crow Song"
11, *73,335 K-ON!! "Gohan wa Okazu"
12, *72,062 Mizuki Nana "Silent Bible" (Lyrical Nanoha game)
13, *69,157 K-ON!! "Pure Pure Heart"
14, *66,083 Angel Beats! "Thousand Enemies"
15, *61,333 Toaru Kagaku no Railgun "Level5 -judgelight-"
16, *59,236 Angel Beats! "Little Braver"
17, *47,121 Heartcatch Precure! "Alright! Heartcatch Precure!" "Heartcatch Paradise"
18, *40,455 Ore no Imouto ga Konnani Kawaii Wake ga Nai "irony"
19, *39,015 K-ON!! Character Image Song Akiyama Mio
20, *38,853 K-ON!! Character Image Song Hirasawa Yui

21, *35,951 Hetalia Axis Powers Character CD vol.7 Russia
22, *35,405 Toaru Kagaku no Railgun "only my railgun" (2009) total sales: 90,837
23, *35,162 Angel Beats! "Last Song"
24, *34,870 Angel Beats! "Ichiban no Takaramono"
25, *33,936 Hetalia Axis Powers Character CD vol.8 China
26, *31,363 Toaru Kagaku no Railgun OVA "future gazer"
27, *28,705 Macross Frontier: Itsuwari no Utahime "CM Ranka"
28, *28,268 K-ON!! Character Image Song Nakano Azusa
29, *25,299 Mahou Shoujo Lyrical Nanoha The Movie 1st "My Wish My Love"
30, *24,799 K-ON!! Character Image Song Tainaka Ritsu
31, *24,430 K-ON!! Character Image Song Kotobuki Tsumugi
32, *23,948 Soredemo Machi wa Mawatteiru & Tamayura "Down Town" "Yasashisa ni Tsutsumareta Nara"
33, *23,201 Suzumiya Haruhi no Shoushitsu "Yasashii Bokyaku"
34, *22,407 Otome Youkai Zakuro "Moon Signal"
35, *22,*** Bakemonogatari "Kimi no Shiranai Monogatari" (2009) total sales: 103,698
36, *22,144 Highschool of the Dead "High School of the Dead"
37, *22,*** K-ON! "Don't say 'lazy'" (2009) total sales: 191,306
38, *21,633 Hayashibara Megumi "Shuketsu no Sadame"
39, *20,840 Toaru Majutsu no Index II "No Buts!"
40, *20,640 Fortune Arterial: Akai Yakusoku "kizunairo"

The rest of the titles to be updated later.

Music Blu-ray
*1, 27,011 K-ON!! Live Event "Let's Go!"
*2, 17,724 Mizuki Nana "Clips 5"
*3, 16,791 Mizuki Nana Live "Diamond x Fever"
*4, 12,354 Hatsune Miku "39's Giving Day"
*5, 11,199 Sakamoto Maaya 15th Anniversary Live "Gift" at Budokan

Source: Youtaiju