According to Dengeki Visual Arts magazine, Baba Takahiro, the President of Visual Arts, said he wanted to ask Kyoto Animation to produce Little Busters! anime, but Kyoto Animation has been quite busy in producing other titles and Visual Arts could not wait for their turn to come. When the TV anime of AIR was produced, the staff of Visual Arts didn't know how to involved in the anime production. Baba said that at that time Kyoto Animation was the only studio which could produce such a wonderful anime without the help of the original creators. However, the great advance in the production of bishoujo anime and years of experiences of Visual Arts with anime producers have convinced Baba that the production studio of Little Busters anime is not necessarily Kyoto Animation.

Baba revealed that the series composer Shimada Michiru had completed the original game including the hidden episode with her daughter. After finishing the game, she checked if she missed something by reading 4.7 MB of the text data of the game scenario.

Game singer Rita announced in her official blog that she will sing the OP theme "Little Busters!" for the TV series. She had been frustrated because she couldn't have an opportunity to sing a theme song of an anime. She sang many theme songs for PC games but the theme song singers were always replaced by someone when the games got anime adaptations. (e.g. Yosuga no Sora) She said the song "Little Busters!" is the most precious song for her and thanked Visual Arts and the anime producers for choosing her. The ED theme of the TV series will also be Rita's "Alicemagic".

Sources: Dengeki Visual Arts, Rita's blog, Key's staff blog